Detalhe da pesquisa
1.
A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.
Cell
; 180(5): 862-877.e22, 2020 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32142679
2.
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.
Cell
; 168(3): 517-526.e18, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28111075
3.
A gut-derived metabolite alters brain activity and anxiety behaviour in mice.
Nature
; 602(7898): 647-653, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35165440
4.
A metabolic pathway for bile acid dehydroxylation by the gut microbiome.
Nature
; 582(7813): 566-570, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32555455
5.
The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE.
J Biol Chem
; 290(22): 13710-24, 2015 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-25855790
6.
The Role of a Nonribosomal Peptide Synthetase in l-Lysine Lactamization During Capuramycin Biosynthesis.
Chembiochem
; 17(9): 804-10, 2016 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26840634
7.
A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW.
Org Biomol Chem
; 14(16): 3956-62, 2016 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-27050157
8.
Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor.
Angew Chem Int Ed Engl
; 52(44): 11607-11, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24014169
9.
Two distinct gut microbial pathways contribute to meta-organismal production of phenylacetylglutamine with links to cardiovascular disease.
Cell Host Microbe
; 31(1): 18-32.e9, 2023 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36549300
10.
Microbe-derived uremic solutes enhance thrombosis potential in the host.
mBio
; : e0133123, 2023 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37947418
11.
Characterization of LipL as a non-heme, Fe(II)-dependent α-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis.
J Biol Chem
; 286(10): 7885-7892, 2011 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21216959
12.
An ATP-independent strategy for amide bond formation in antibiotic biosynthesis.
Nat Chem Biol
; 6(8): 581-6, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20562876
13.
HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non-Small Cell Lung Cancer.
Clin Cancer Res
; 28(2): 390-403, 2022 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34921025
14.
Functional and kinetic analysis of the phosphotransferase CapP conferring selective self-resistance to capuramycin antibiotics.
J Biol Chem
; 285(17): 12899-905, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20202936
15.
Target deconvolution from phenotype-based drug discovery by using chemical proteomics approaches.
Biochim Biophys Acta Proteins Proteom
; 1867(1): 22-27, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30392561
16.
The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase.
Chembiochem
; 11(2): 184-90, 2010 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20043306
17.
The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage.
Medchemcomm
; 4(1): 239-243, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23476724
18.
A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405.
J Antibiot (Tokyo)
; 64(7): 495-501, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21587261
19.
Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196.
J Antibiot (Tokyo)
; 62(6): 325-32, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19478828
20.
Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus.
J Biol Chem
; 283(20): 13983-91, 2008 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-18364359